Ethyl difluoro-bromoacetate manufacturer introduces the synthesis process classification of ethyl difluoro-bromoacetate

Ethyl fluoroacetate manufacturer_Ethyl difluoro-bromoacetate compound is an intermediate in the synthesis of drugs and high energy materials, such as ethyl difluoro-bromoacetate is an intermediate of the drug gemcitabine, its chemical properties are boiling point 112 ℃, density 1.583. ethyl difluoro-bromoacetate is a colorless transparent liquid, it is an important synthesis intermediate, commonly used in the synthesis of drugs with biological enzyme system function and the synthesis of pesticides, etc.
　　Ethyl fluoroacetate manufacturer_Ethyl difluoro-bromoacetate belongs to ester derivatives, which can be used as pharmaceutical intermediates, while ethyl difluoro-bromoacetate compound is an intermediate for the synthesis of drugs and high energy materials, such as ethyl difluoro-bromoacetate is an intermediate for the drug gemcitabine, its chemical properties are boiling point 112℃, density 1.583. ethyl difluoro-bromoacetate is a colorless transparent liquid, which is an important synthesis intermediate. It is often used in the synthesis of drugs with biological enzymatic functions and the synthesis of pesticides, etc. In ethyl difluoro-bromoacetate, the biologically active CF2 is introduced into the compound by replacing the bromine atom, and the fluorine in the α-position of these compounds increases the electrophilicity of the carbonyl group, i.e., increases the active site of the biological enzyme. Fluorine atoms are bioelectronic equivalents of hydroxyl groups, and difluoromethylenes are also considered to be bioelectronic equivalents of ethoxy groups, and compounds containing difluoromethylenes are useful bioactive reagents.
　　Ethyl fluoroacetate manufacturer_The synthesis process of ethyl difluorobromoacetate is classified as follows
　　1. Using tetrafluoroethylene as raw material
　　To synthesize bromodifluoroacetyl chloride from tetrafluoroethylene, tetrafluoroethylene and sodium methanol are formed into trifluorovinyl methyl ether at 60℃. Then it was added with bromine and then oxidized to remove the ether to obtain bromodifluoroacetyl chloride. However, the yield of this reaction is relatively low, and the yield of ethyl difluoroacetyl chloride is about 30 percent based on tetrafluoroethylene.
　　2. Vinyl trifluoride as raw material
　　The raw material of vinyl trifluoride was used to synthesize CF2Br CFCl Br, and then oxidized with sulfuric acid and sulfur trioxide. 40% of fuming sulfuric acid with the molar ratio of SO3/CF2Br CFCl Br equal to 1.5 was reacted for 20h to obtain bromodifluoroacetyl chloride with a yield of 85%, and ethyl difluoroacetate was obtained by separating the obtained bromodifluoroacetyl chloride and leaving it in anhydrous ethanol.